PKRRATING - AN OVERVIEW

3B). R526 through the loop amongst αJ and αI anchors the C-terminal percentage of the activation loop by forming a salt bridge with E458 at The bottom of αEF. Q459 stabilizes the HRD motif by a hydrogen bond to the primary chain carbonyl of R413. The tip in the activation section is stabilized by a hydrogen bond among Y454 and E480 from αfile.